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KMID : 0358420150580040302
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Korean Journal of Obstetrics and Gynecology
2015 Volume.58 No. 4 p.302 ~ p.308
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Dose-response relationship between cigarette smoking and female sexual dysfunction
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Choi Joo-Hee
Shin Dong-Wook
Lee Seung-Mee
Jeon Myung-Jae
Kim Sun-Min
Cho Be-Long
Lee Seung-Mi
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Abstract
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Objective: To evaluate whether smoking is a risk factor for female sexual dysfunction (FSD) and to determine the relationship between the cumulative smoking dose and FSD in premenopausal women.
Methods: The study population consisted of sexually active premenopausal women. The frequency of FSD and female sexual function index (FSFI) total score were evaluated according to the smoking status (never/former and current smokers). Evaluation of sexual function was done using FSFI questionnaire, and women with FSFI score of ≤26.55 were considered to have FSD. In current smokers, sexual function was also evaluated according to the cumulative smoking dose and nicotine dependency.
Results: A total of 900 women were included, and the frequency of current smokers and the frequency of FSD were 62 (6.9%) and 496 (55.1%), respectively. In current smokers, the frequency of FSD was significantly higher and the median total FSFI score was significantly lower than in never/former smokers, and this difference of FSD remained significant after adjustment for confounding variables. Among current smokers, the cumulative smoking dose (pack-years) and the total FSFI score showed negative correlation, in which increased cumulative smoking dose was associated with lower total FSFI score (r=-0.278, P<0.05). In terms of nicotine dependency, the total FSFI score of moderately to heavily nicotine dependent smokers was significantly lower than that of lightly dependent smokers.
Conclusion: In premenopausal women, current smoking was an independent risk factor for FSD. And cumulative smoking dose and nicotine dependency were associated with higher risk of FSD.
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KEYWORD
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Dose-response relationship , Female , Nicotine , Sexual dysfunctions , Smoking
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